Supporting Study to Transform En-Route Care System
|Potential UCARE Research Position?||
1/8/2018 but flexible
|Paid or Volunteer||
|Hours Per Week||
We will develop and validate proof-of-concept peritoneal and thoracic microbubble oxygenation as a mitigation strategy for Acute Respiratory Distress Syndrome (ARDS). Previous studies have demonstrated this technology has potential to augment oxygenation via bypass of damaged lung parenchyma.
The technology provides rapid oxygen delivery without the anticoagulants that are required for other lung bypass methods, such as extracorporeal membrane oxygenation (ECMO) therapy. Use of anticoagulant agents becomes particularly problematic in traumatically injured personnel, when intracranial hemorrhage or other injuries may be worsened by its use. A portable microbubble oxygenation system could provide sufficient levels of blood oxygenation to enable survivable transportation from remote and far-forward environments to field and rear-area hospitals.
The tasks of this project may include: characterizing the physiology of OMB treatment for abdominal versus chest infusion routes, developing methods to stabilize, store and reconstitute OMBs for forward deployment, engineer prototype devices for continuous and bolus infusion of OMBs, and, evaluating dosage and toxicity of OMBs.